Experience the revitalizing power of polynucleotides to smooth wrinkles, boost collagen and rejuvenate your skin.

Transform, Rejuvenate and Regenerate Your Look with Polynucleotides.

Indulge in the epitome of aesthetic innovation with our exclusive polynucleotide treatments at Millennium Aesthetics – the coveted choice of discerning individuals seeking age-defying allure and unparalleled results.

Under the expert care of Dr. Jan, Polynucleotides/Nucleotides therapies are designed to:

  • Rejuvenate your skin, making it look and feel younger – lines and wrinkles are diminished
  • Prevent premature ageing (prejuvenation)
  • Biorevitalisation – profoundly stimulating the skin at a cellular level – resetting the skin’s production mechanisms
  • Powerfully stimulate collagen and elastin production – making your skin stronger and more resilient with each injection – newer, younger and fresher skin is the result
  • Prime the skin so that it can behave better in response to other aesthetic procedures such as Tixel or Laser
  • Enhance overall skin quality and glow
  • restore a youthful, vibrant appearance without drastically changing your appearance – it’s still you but better!


Polynucleotides/nucleotides are the ideal game-changer you’ve been longing for, especially if you’ve always desired better skin quality or less tired-looking eyes.  

Skin quality is paramount in any aesthetic result, as it effectively drapes and showcases the underlying enhancements. If your skin is suboptimal, even the best aesthetic treatments can fall short. Treating the skin with polynucleotides before any further cosmetic treatments can really help to refine and improve the condition of your skin, making results from any further tweakments look smoother and more refined/polished.

Polynucleotides are naturally occurring purified DNA fragments (expertly extracted from Trout/Salmon) that stimulate fibroblast growth and activity, prompting your skin to behave like it did when you were younger. They have been used safely for many years in wound healing, demonstrating an excellent safety profile and making them a reliable option for aesthetic skin therapies since 2003.  Since 2015, polynucleotides have also been combined with hyaluronic acid to form polynucleotide fillers – these have been shown to provide a longer-lasting effect than hyaluronic acid (HA) alone – providing a safe yet effective alternative to HA fillers for facial rejuvenation, especially in mature skin. And, since 2021, polynucleotide-based hair restoration treatments have grown in popularity  – both as a way of priming the scalp before hair transplant surgery as well as being an effective stand-alone solution for managing hair loss.

Polynucleotides offer a multi-faceted approach to skin rejuvenation: 

  • They are powerful antioxidants, protecting the skin from free radical damage and environmental stressors that can damage the skin 
  • Anti-inflammatory and promotes wound healing – especially great for acne/acne scarring
  • deeply moisturising and hydrating – skin is softer, dewy and looks fresher
  • Increase blood flow
  • Reduce pigmentation (melanogenesis)
  • improves skin tone, elasticity and suppleness 
  • diminishes unwanted pigmentation and sun damage. 

Many patients who are unsuitable for tear trough filler or hesitant about eye surgery find polynucleotides to be an ideal solution. Imagine the confidence boost you’ll experience as your dark circles fade and your skin regains its youthful glow—no more concealer collecting in the creases around your eyes! Book your appointment now and let your eyes tell a story of timeless beauty with a more radiant gaze no filter required.

The benefits of this treatment extend beyond mere aesthetics – with polynucleotides, you can achieve a more positive, friendly and approachable look; they enhance your overall sense of well-being, appearance and confidence. Whether you’re dealing with pigmentation issues, sun damage, or simply the effects of ageing, polynucleotides offer a non-invasive, highly effective solution that does not add unnecessary volume to the skin. Patients often express their satisfaction to Dr Jan by praising the treatment for its remarkable yet natural long-term results as well as the renewed self-esteem it brings.  It is currently the most popular and trending treatment in most aesthetic clinics in the UK!

At Millennium Aesthetics Clinic, Dr. Jan is dedicated to providing top-tier aesthetic treatments tailored to each patient’s unique needs. From your initial consultation to the final result, you can expect personalised care, comfort and kind attention. 

Book your consultation with Dr. Jan today and invest in your skin’s long term future.  Discover how polynucleotides can transform your skin, boost your confidence and help you achieve the radiant, youthful appearance you’ve always desired.  Looking good and feeling great is just an appointment away with Dr Jan and Polynucleotides!


Before & After


After 3 treatments


After 3 treatments of polynucleotides and Tixel

before polynucleotides injection

immediately after polynucleotides injection

Polynucleotides are biostimulatory treatments derived from purified DNA fragments, often from salmon or trout. These molecules work at a cellular level to stimulate collagen production, enhance tissue regeneration, and improve overall skin health.

Polynucleotides stimulate fibroblast activity, encouraging the skin to produce more collagen and elastin. This process rejuvenates the skin, making it firmer, more hydrated, and reducing the appearance of fine lines and wrinkles.

Polynucleotides can effectively treat a variety of skin concerns, including fine lines and wrinkles, sagging skin, pigmentation, sun damage, and dull complexion. They are also suitable for improving under-eye circles and revitalising tired-looking eyes.

Unlike hyaluronic acid fillers that primarily add volume and hydration, polynucleotides promote deep tissue regeneration and skin biorevitalisation. This leads to longer-lasting improvements in skin texture, elasticity, and overall appearance without significantly altering facial contours.

This treatment is suitable for individuals looking to improve their skin quality, reduce signs of ageing, or address specific issues like pigmentation and dark circles. It’s particularly beneficial for those who may not be ideal candidates for tear trough fillers or who prefer a non-surgical option.

Yes, polynucleotide treatments may not be suitable for everyone. Individuals with fish allergies should avoid this treatment as polynucleotides are often derived from salmon or trout. Additionally, those who adhere to a strict vegan or vegetarian lifestyle may opt out of this treatment due to its animal-derived components. Polynucleotides are not recommended for women who are pregnant or breastfeeding. 

It’s important to discuss any allergies, dietary preferences, or medical conditions with Dr. Jan during your consultation to ensure this treatment is safe and appropriate for you.

The procedure typically involves applying a numbing cream followed by precise injections of the polynucleotide solution. The treatment is quick, minimally invasive, and has little to no downtime. Patients might experience some redness or swelling, which usually subsides within a few hours. Occasionally there can be bruising.  Noticeable results can be seen within 2 weeks, with optimal outcomes following a recommended course of treatments – usually 3-4 spaced 2-3 weeks apart.

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